February 2018
Dear Researcher,
We are pleased to present the e-Lynx, a newsletter devoted to keeping our customers up-to-date on new technologies, our new products, suppliers, activities and promotions.
- New Products
- New Videos
- Promotions
- Technical Report
- MJSBioLynx Well Being
NEW PRODUCTS
Platypus Technologies – Gold-coated Silicon Wafers
Platypus Technologies uses only 99.999% pure gold and titanium in their coating process, and coat only those substrates that are stable under high vacuum. This eliminates concerns about contamination from previous coating runs.
- 4" diameter 525 um thickness silicon wafer
- 50 nm of gold over a Titanium adhesion layer
Click here to order or request a quote.
G-Biosciences – Mitochondrial Assays
TMRE Mitochondrial Membrane Potential Assay quantifies changes in mitochondrial membrane potential of live cells via microplate fluorometry. Cells with active mitochondria can be stained with TMRE in under 30 minutes.
JC-1 Mitochondrial Membrane Potential Assay comprise of lipophilic cationic fluorescent dye; 5,5,6,6’-tetrachloro-1,1’,3,3’-tetraethylbenzimi-dazoylcarbocyanine iodide (JC-1), that forms aggregates in mitochondria of healthy cells emitting bright red fluorescence. Stains live cells in under 30 minutes.
Click here to order or request a quote.
NEW VIDEOS
Mirus – Recorded Webinar: Addressing the Challenges of Therapeutic Vector Development
This webinar will discuss factors that are critical for viral vector development from the analytical scale to larger clinical-scale manufacturing modalities. Drawing attention to these parameters will ultimately lead to better downstream transductions for gene expression and knockdowns or genome editing.
Click here to watch. (Link to YouTube)
Cygnus Technologies – Recorded Webinar: Improved Methods for Host Cell Protein Analysis
A comprehensive analysis of HCP impurities requires the integration of data from orthogonal methods with the sensitivity to analyze those HCPs that actually co-purify with the product. While ELISA is the gold standard and will likely remain as the release test, qualification of the ELISA and validation of purification processes necessitate implementation of orthogonal methods with the sensitivity to detect and identify individual HCPs. This talk will discuss how methods like Antibody Affinity Extraction and Mass spectrometry can be combined with sound ELISA development to achieve a more complete analysis of HCP content than has been traditionally required by regulatory agencies.
Click here to watch (Link to Cambridge Innovation Institute Website)
PROMOTIONS
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Micronic – 2018 Kick-off Bundle Deals
These offers will help improve your workflow by automating the process of (de)capping sample storage tubes. You can also ensure complete traceability of your tissue samples with the Tissue Storage Starter Pack.
Buy a Screw Cap Recapper SR008 and Screw Caps with a 20% Bundle Discount
The Recapper SR008 handheld device offers users the ability to cap, decap or recap a row of 8 tubes in less than 5 seconds! This system minimizes sample evaporation, significantly improves productivity, and ensures each screw cap is tightened securely and uniformly.
Click here to order.
Buy a Push Cap Capper CM480 and Push Caps with a 20% Bundle Discount
The CM480 Capper offers a cost effective way of applying uniform pressure to push caps in an entire 96 tubes rack in only a single action.
Click here to order.
Buy a Tissue Storage Starter Pack with 1.00mL or 3.50mL Tubes with a 20% Bundle Discount*
Micronic Starter Packs contain everything needed to start using 2D coded sample storage tubes, enabling laboratory workers to maintain a secure sample logistics system and eliminate the costly possibility of false sample identities.
Click here to order.
Offers Valid until March 31st, 2018.
Cannot be combined with other offers or discounts.
*Compared to price of purchasing products separately.
USA Scientific - FREE Pizza Party Promotion
For the cold Canadian winter months of January to March 2018, enjoy hot, delicious pizza on us!
Accumulate $500 in Purchases of USA Scientific Products from MJSBioLynx and Receive a $50 Pizza Gift Certificate*.
USA Scientific offers cell culture labware, pipets and tips, plates, tubes and much more.
Click here to order or to request a quote.
Please reference Promotion Code US2018PZA.
Offer valid until March 31st, 2018.
Limit: Two pizza parties per lab; Cannot be combined with other offers.
* Please note that if you purchase $500 in USA Scientific products during our promotion period but are unable to accept our pizza gift we would be pleased to offer you a $50 voucher towards your next order of $100 or more of USA Scientific products. Coupons are valid until April 30th, 2018.
TECHNICAL REPORT
Hycult - The Role of Complement in Infection-induced Hemolytic Uremic Syndrome
Summary of Westra, D. et al; Serological and genetic complement alterations in infection-induced and complement-mediated hemolytic uremic syndrome. Click here for the full article.
The role of complement in the atypical form of hemolytic uremic syndrome (aHUS) has been extensively studied. However, less is known about the role of complement in infection-induced HUS. In a majority of these cases, the disease is triggered by an infection with Shiga-like toxin-producing Escherichia coli (STEC-HUS). Based on the similarity of the clinical manifestations of complement-mediated and infection-induced HUS, this study hypothesizes that also here the dysregulation of the complement system has an important place in the pathogenesis.
To determine the role of the alternative complement pathway (AP), 37 pediatric patients were enrolled in this study. 26 patients had STEC-HUS and 11 were diagnosed with aHUS. EDTA plasma was taken from the patients and used for testing a variety of complement factors and components, such as C3, CFH, CFI and TCC (Product Number HYBHK328). Results show that TCC was only significantly increased in STEC-HUS patients in the acute phase […] making it useful in monitoring the course of the disease. Taken all aspects together it is clear that measuring AP activation products, in particular C3d/C3 ratio, might help in monitoring disease activity and distinguishing between the different HUS etiologies. The exact role of altered complement activation in the pathogenesis of STEC-HUS, however, has not been fully elucidated.
MJSBioLynx WELL BEING
Physical Activity Reduces Fatigue in Patients with Cancer and Hematopoietic Stem Cell Transplant Recipients: A Systematic Review and Meta-analysis of Randomized Trials
"Purpose: Objective was to determine whether physical activity reduces the severity of fatigue in patients with cancer or hematopoietic stem cell transplant (HSCT) recipients.
Methods: We conducted a meta-analysis of randomized trials comparing physical activity with control interventions for the management of fatigue in patients with cancer or HSCT recipients.
Results: There were 170 trials included. Physical activity reduced the severity of fatigue when compared to all control groups (standardized mean difference−0.49, 95% confidence interval−0.60 to−0.37; P < 0.00001). Aerobic, neuromotor, resistance and combination exercises were all effective in reducing fatigue although smaller effects were observed with resistance exercises (P interaction = 0.01). Other intervention and patient characteristics did not influence the effect of physical activity on the severity of fatigue.
Conclusions: Physical activity was effective at reducing fatigue in patients with cancer and HSCT recipients across patient sub-groups. Determining the best approaches for safe implementation should be a priority."
Click here to read more. (Link to Critical Reviews in Oncology / Hematology website)
Click here to visit the MJSBioLynx Well Being website